Can Cannabidiol Help Prevent and Treat Gastrointestinal Disorders? Insights from Experts

Numerous people search for a “cannabis store near me” to acquire marijuana, whether for therapeutic reasons or recreational enjoyment. It is widely recognized that cannabis products may assist in alleviating symptoms such as anxiety, depression, pain, nausea, and vomiting. Have you thought about its impact on gastrointestinal disorders?

Key Takeaways:

• The cannabinoids in the plant interact with the endocannabinoid system within the GI tract.
• Cannabis and pain medications may aid in managing Irritable Bowel Syndrome symptoms.
• cannabis serves various functions, yet many are familiar with its recreational and medical uses.

Gastrointestinal Disorders and Canada Wide Weed Shop

The dietary impact of nutraceuticals on gastrointestinal health is well recognized. Certain diets have the potential to prevent or alleviate various GI conditions. Researchers have pinpointed, isolated, and assessed the food components responsible for these benefits.

Among the plant-based nutraceuticals that may be useful for treating GI disorders are those derived from cannabis. cannabis refers to products sourced from the cannabis Sativa plant, a fragrant annual flowering herb.

John M. McPartland concluded in a scientific review that the Cannabaceae family includes the genera Cannabis, Humulus, and Celtis. Within the cannabis genus, sativa contains three varieties: Sativa, Indica, and Ruderalis. Depending on the variety, cannabis sativa serves diverse purposes, such as fiber production, oil extraction from seeds, and primarily, recreational or medicinal uses.

The Impact of the Plant

Receptors and ligands of the endocannabinoid system are distributed throughout various areas and systems, both inside and outside the GI tract, which are crucial for regulating GI functions. Due to the presence of cannabinoid receptors, cannabinoids, including non-psychoactive phytocannabinoids, help modulate GI functions in both health and disease conditions. The ECS plays a role in regulating motility, secretion, epithelial barrier function, and viscerosensitivity.

Irritable Bowel Syndrome (IBS)

IBS has various contributing factors, affecting 10–20% of individuals in developed countries. It presents as functional gastrointestinal disturbances with no identifiable organic causes.

The enhancement of the antinociceptive properties of cannabinoids in the presence of inflammation highlights the importance of the ECS in visceral hypersensitivity. This insight not only clarifies the mechanisms behind conditions like IBS and other GI disorders but also suggests promising therapeutic strategies for relieving abdominal and visceral pain.

Cannabinoids on their own might not provide substantial relief in reducing visceral hypersensitivity among IBS patients. Investigating combinations with other pain-modulating agents, such as opioids, presents an interesting alternative worth exploring.

Inflammatory Bowel Disease (IBD)

IBD, including Crohn’s disease and ulcerative colitis, is a complex condition of the GI tract, stemming from environmental, genetic, and epigenetic factors.

Cannabidiol exhibits significant anti-inflammatory properties across various models of intestinal inflammation in rodents, as noted in a study published in the Journal of Frontiers in Pharmacology. Both local and systemic administration of CBD displayed a dose-dependent improvement in disease indicators:

• Reduced structural damage
• Decreased inflammation-related increases in cytokines, chemokines, and oxidative stress markers.

A study from the Inflammatory Diseases Journal indicated that the primary finding was the challenging tolerability of the botanical extract, with 90% of patients experiencing treatment-related side effects compared to 48% of those receiving a placebo.

A trend was observed towards improved quality of life scores and a favorable change in patients’ overall impressions, according to the per-protocol analysis. The authors speculate that the CBD-rich botanical extract could offer therapeutic benefits to those patients who can tolerate its effects.

Gastrointestinal Cancer

GI cancers, such as colorectal cancer, rank among the most frequently diagnosed conditions in the general population.

Various studies have demonstrated CBD’s antiproliferative effects in colorectal cancer models. CBD can protect DNA from oxidative stress, elevate endocannabinoid levels, and inhibit the proliferation of colorectal cancer cells in vitro.

The confirmation of CBD’s chemopreventive properties emerged from investigations using in vivo models focused on AOM-induced colon cancer. CBD at a dosage of 1 mg/kg resulted in a significant reduction: ACF decreased by 67%, while the number of tumors and polyps fell by 66% and 57%, respectively. Increasing the concentration to 5 mg/kg proved effective mainly in preventing polyp formation.

THC induces apoptosis in colorectal cancer cells by activating the CB1 receptor.

Nausea and Vomiting

Positive effects of CBD occur when paired with THC, as indicated in a study published in the British Journal of Clinical Pharmacology. CBD’s anti-nausea and anti-emetic properties may stem from the indirect stimulation of somatodendritic 5-HT1A receptors located in the dorsal raphe nucleus. This activation of autoreceptors potentially reduces the release of 5-HT in specific forebrain regions.

Gastroesophageal Reflux Disease (GERD)

Cannabinoids inhibit transient LES relaxations via a CB1-dependent mechanism in various animal studies, as reported in the Journal of Cannabis and Cannabinoid Research. These findings are significant since transient LES relaxations are the primary mechanism underlying gastroesophageal reflux disease.

cannabis for GI Issues

Conclusion

Numerous studies suggest that the advantages of cannabinoids extend beyond the well-known psychoactive compound THC to include non-psychoactive compounds like CBD, which have received comparatively less focus. The cannabis plant influences the GI system by engaging with the ECS to trigger multiple functions, potentially assisting in managing symptoms of specific GI conditions.

Frequently Asked Questions

What can you expect when buying from online Canada Wide Weed Shop?

1. Accessing your cannabis products in Canada from an online store provides numerous options featuring both classic favorites and new arrivals.
2. Expect additional perks such as exclusive offers, secure payment methods, and shipping options that cover most provinces.
3. Essential resources, like a blog section or contact page, are available to offer insights or assistance during your shopping journey.
4. As part of the purchasing process, you will need to verify your age by providing identification.
5. Some stores include taxes in their product prices, while others calculate them at checkout.
6. Certain dispensaries accept online payments like Interac E-Transfer, while others permit cash on delivery.

What is the measurement unit when buying from a cannabis website?

There are two main forms of measurement: metric and imperial units. On a cannabis site, you’ll find measurements in grams or ounces, making it easy to locate products like 3.5 grams or 1/8 ounces.

What distinguishes cannabis for medical use from that used recreationally?

Medical cannabis and recreational cannabis come from the same plant species, yet their differing effects and intended purposes differentiate them. Medical cannabis serves as a therapeutic aid for specific health conditions, typically containing a higher CBD composition compared to its recreational variant.

Are there ready-made joints available in a cannabis store?

Yes, these are available as pre-rolls. cannabis pre-rolls, or pre-rolled joints and blunts, offer convenient options for those who prefer their cannabis ready for use. The popularity of pre-rolled joints infused with cannabis concentrates is on the rise.

Do cannabis online stores have a physical shop?

Not all online stores maintain physical locations, allowing you to receive your purchases directly at home without needing to pick them up from a physical store after placing an order online.